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Animals ( n = 68 per group) were treated with AMPT to cause dopamine depletion and were placed in open-field chambers for 15 min

Obviously, if there's any sort of vagal nerve dysfunction, you're stuck in this dysautonomic sympathetic driven state

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While no evidence directly links BPC-157 to cancer development, individuals with cancer history or active malignancy should avoid use

Continuous administration without washout can lead to adaptive downregulationwhere receptors become less responsive to MOTS-c signaling or NNMT inhibition becomes less effective due to compensatory upregulation